P0300 on GMC YUKON — Random/Multiple Cylinder Misfire Detected

Q: "What does P0300 mean on a GMC YUKON?"

"P0300 indicates: Random/Multiple Cylinder Misfire Detected. This is a ignition system code. 3 GMC YUKON owners have reported this to NHTSA."

Q: "What are the most common causes of P0300 on GMC YUKON?"

"Based on 3 NHTSA reports, the most commonly cited components are: Engine, Engine,Fuel/Propulsion System, Power Train,Engine. These percentages are based on the component field in owner complaints."

Q: "Is P0300 serious on my GMC YUKON?"

"Of 3 NHTSA reports for this code on GMC YUKON, none involved a crash or fire. However, any diagnostic code should be evaluated by a qualified mechanic."

Q: "What should I do if my GMC YUKON shows P0300?"

"1) Check for recalls on your VIN at nhtsa.gov/recalls. 2) Get a professional diagnosis — a code alone doesn't identify the exact failed part. 3) Get 2-3 repair estimates to compare."

What P0300 Means on Your GMC YUKON

P0300 is a diagnostic trouble code indicating: Random/Multiple Cylinder Misfire Detected. This code relates to the ignition system system. The vehicle's computer detected a condition outside normal operating parameters and stored this code.

3 GMC YUKON owners have reported this issue to NHTSA across model years 2020-2025. Most reports come from the 2020, 2021 model years.

Real GMC YUKON Owner Reports

Source: NHTSA Complaints Database

"I purchased a new 2020 GMC Yukon in May of 2020. Between May 2020 and November 2025 the vehicle was routinely serviced on or before the due date recommend by the manufacturer."

— 2020 GMC YUKON owner · ENGINE · Filed 11/04/2025

"I got 3 messages on the dash going off simultaneously 1. Service Traction Control System 2. Forward Collision System unavailable 3."

— 2021 GMC YUKON owner · ENGINE,FUEL/PROPULSION SYSTEM · Filed 11/22/2025

"While driving on a highway, the vehicle intermittently suffers a sudden loss of engine power during acceleration, accompanied by a flashing check engine light."

— 2025 GMC YUKON owner · POWER TRAIN,ENGINE · Filed 10/25/2025

All reports filed by vehicle owners directly with the U.S. Department of Transportation.

📊 Complaint Trend by Model Year

1

'20

1

'21

1

'25

Common Causes on GMC YUKON

Based on NHTSA complaint component analysis for this vehicle.

ENGINE 33.3%

ENGINE,FUEL/PROPULSION SYSTEM 33.3%

POWER TRAIN,ENGINE 33.3%

What To Do Next

1
Check for recalls on YOUR VIN
Go to nhtsa.gov/recalls and enter your VIN. If your vehicle is covered, repairs are free.
2
Get a proper diagnosis
A code alone doesn't tell you the exact failed part. A diagnostic at a shop ($50–$150) pinpoints the root cause before you spend money on parts.
3
Compare repair quotes
Get 2–3 quotes. Dealer vs. independent shop prices often differ 30–50% for the same repair.

Frequently Asked Questions

What does P0300 mean on a GMC YUKON? ▾

P0300 indicates: Random/Multiple Cylinder Misfire Detected. This is a ignition system code. 3 GMC YUKON owners have reported this to NHTSA.

What are the most common causes of P0300 on GMC YUKON? ▾

Based on 3 NHTSA reports, the most commonly cited components are: Engine, Engine,Fuel/Propulsion System, Power Train,Engine. These percentages are based on the component field in owner complaints.

Is P0300 serious on my GMC YUKON? ▾

Of 3 NHTSA reports for this code on GMC YUKON, none involved a crash or fire. However, any diagnostic code should be evaluated by a qualified mechanic.

What should I do if my GMC YUKON shows P0300? ▾

1) Check for recalls on your VIN at nhtsa.gov/recalls. 2) Get a professional diagnosis — a code alone doesn't identify the exact failed part. 3) Get 2-3 repair estimates to compare.